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pentobarbital will lessen the level or outcome of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lessen the level or outcome of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration. Sturdy or reasonable CYP3A inducer